Learn 12 questions from Pharmacist Grade II

Pharmacist Grade II Questions

 ii) Powerful oxidising and weak reducing agent. 

iii) Its stability is increased by making it slightly acid and addition of small quantities of preservatives.

<ul style="color: rgb(255,255,255);"><li>Primaquine is a synthetic 8-aminoquinoline drug primarily utilized for the radical cure of Plasmodium vivax and Plasmodium ovale malaria.</li><li>It is the only clinically available agent in the 8-aminoquinoline class that effectively destroys the dormant liver stages (hypnozoites) of these malaria parasites, thereby preventing clinical relapse.</li><li>Mechanism of Action: It acts as a tissue schizonticide and also exhibits gametocytocidal activity, which helps in interrupting the transmission of the parasite from humans to mosquitoes.</li><li>Safety Concern (G6PD Deficiency): A critical clinical consideration is that Primaquine can induce severe hemolysis (destruction of red blood cells) in patients with a genetic deficiency of the enzyme Glucose-6-Phosphate Dehydrogenase (G6PD).</li><li>Historical Context: Developed during the 1940s, it remains a cornerstone in malaria eradication strategies because it is the only currently approved medication capable of clearing the liver reservoir of parasites.</li><li>Other 8-Aminoquinolines: While other derivatives like Tafenoquine have been developed more recently as single-dose alternatives, Primaquine continues to be the standard regimen for radical cure, typically administered over a 14-day course.</li></ul>

 Potent vasoconstrictor and cardiac stimulant

Challenger App

No.1 PSC Learning App