Question

How many steps of decarboxylation lead to the formation of ketoglutaric acid?

• A. One
• B. Three
• C. Two
• D. Seven

Answer 1

Answer:

C. Two

• Two steps of decarboxylation leads to the formation of ketoglutaric acid.

• When citric acid is formed in the cycle, it then forms cis-acotinic acid and then isocitric acid.

• Isocitric acid further forms oxalosuccinic acid which finally forms ketoglutaric acid in the presence of oxalosuccinate decarboxylase enzyme.