Question

Select the incorrect statement from the following:

• A. NAD+ is produced during reduction of acetaldehyde to ethanol
• B. Enzymes of citric acid cycle are located in the mitochondrial matrix in eukaryotes.
• C. Cyt a3 possesses two copper centers that helps in transfer of electrons to oxygen
• D. Blocking of hexokinase does not affect glycolysis significantly

Answer 1

Answer:

D. Blocking of hexokinase does not affect glycolysis significantly

• Inhibition of hexokinase by small interfering RNA (siRNA)-mediated knockdown reduces the migratory behavior of VSMC without affecting cell viability .

• Upon increased glycolytic flux, the activity of hexokinase-II increases which in turn incites hypoxia-inducible factor 1 (HIF-1) to cause proliferation of VSMCs.

• Also, stimulation of HIF-1 increases the expression of HK-II resulting in apoptotic resistance in VSMC