Question

The cells which secrete perforin are:

• A. Plasma cells
• B. suppressor cells
• C. Helper T cells
• D. Killer T cells

Answer 1

Answer:

D. Killer T cells

• Perforin is a pore-forming glycoprotein that helps Killer T cells and NK cells kill infected or abnormal target cells by forming pores in their membranes.

• This allows granzymes to enter target cells and induce apoptosis (programmed cell death).

• While primarily secreted by CD8+ cytotoxic T cells and NK cells, CD4+ T cells can also produce perforin but in smaller amounts under specific conditions.