Question

Which of the following antibiotic acts by competitively inhibiting the peptidyl transferase activity of prokaryotic ribosomes?

• A. Puromycin
• B. Vancomycin
• C. Tetracycline
• D. Chloramphenicol

Answer 1

Answer:

D. Chloramphenicol

• Chloramphenicol is a broad-spectrum antibiotic that acts by competitively inhibiting the peptidyl transferase activity of prokaryotic ribosomes.

• It binds to the larger subunit, near the A site.