Question

Enzyme converts uric acid into more soluble derivative, allantoin, in mammals

• A. uricase
• B. uriase
• C. Allantoinase
• D. None of these

Answer 1

Answer:

A. uricase

The enzyme uricase, also known as urate oxidase, converts uric acid into allantoin in most mammals In humans, the uricase enzyme is nonfunctional due to a frameshift mutation that occurred during evolution. This means that uric acid, a weak acid that is relatively insoluble, is the end product of purine metabolism in humans. High blood uric acid levels are associated with a number of health issues, including gout, cardiovascular disease, and diabetes. Low urate levels, on the other hand, may increase the risk of neurodegenerative diseases.