Question

Lipoprotein with fastest electrophoretic mobility :

• A. HDL
• B. LDL
• C. VLDL
• D. Chylomicron

Answer 1

Answer:

A. HDL

Lipoprotein Electrophoretic Mobility

• Alpha-lipoproteins (HDL): These possess the fastest electrophoretic mobility among all lipoprotein classes. In serum protein electrophoresis, they migrate to the alpha-globulin region.

• Beta-lipoproteins (LDL): These exhibit slower mobility compared to alpha-lipoproteins, migrating to the beta-globulin region.

• Pre-beta lipoproteins (VLDL): These migrate between the alpha and beta regions, specifically at the pre-beta position.

• Chylomicrons: These are the largest lipoproteins with the lowest density. Due to their large size and high lipid content, they remain at the origin during electrophoresis and do not migrate significantly.

Summary of Migration Pattern (Fastest to Slowest):

1. Alpha-lipoprotein (HDL) - Fastest

2. Pre-beta lipoprotein (VLDL)

3. Beta-lipoprotein (LDL)

4. Chylomicrons - Remain at the origin (Slowest/No migration)