Question

Replacement of glutamic acid by valine in haemoglobin causes:

• A. Thalassemia
• B. Sickle cell anaemia
• C. Haemophilia
• D. Albinism

Answer 1

Answer:

B. Sickle cell anaemia

• In sickle cell anaemia, base substitution from glutamic acid to valine occurs at the relevant portion of the beta chain of the haemoglobin molecule.

• This substitution occurs due to the single base substitution at the sixth codon of the beta globin gene from GAG to GUG.