Bombay blood group lacks :
AA antigen
BH antigen
CB antigen
DAll of these
Answer:
D. All of these
Read Explanation:
- The Bombay blood group (also known as the hh blood group or Oh phenotype) is characterized by the complete absence of the H antigen on the surface of red blood cells.
- In the standard ABO blood group system, the H antigen is the essential precursor for the synthesis of A and B antigens. Without this precursor, A or B antigens cannot be formed, even if the person possesses the corresponding genes.
- Individuals with this phenotype are homozygous recessive for the H gene, represented as hh.
- This rare blood group was first identified by Dr. Y.M. Bhende in 1952 in Mumbai (then Bombay), India.
- A person with the Bombay blood group can produce antibodies against the H antigen (anti-H antibodies). Consequently, they can only receive blood transfusions from other individuals who also possess the Bombay blood group.
- If a Bombay phenotype individual receives blood from someone with O, A, B, or AB blood groups, it can lead to a severe hemolytic transfusion reaction because the donor blood contains the H antigen, which the recipient's immune system will attack.
- While they lack the H antigen, their plasma contains anti-A, anti-B, and anti-H antibodies, making them universal donors for the ABO system (in terms of red blood cell compatibility) but extremely limited in terms of who they can receive blood from.